Job satisfaction has been extensively studied in the fields of organizational behavior and human resource management. However, because the factors influencing job satisfaction are highly diverse and the relationships among them are considerably complex, research in this area has yet to produce satisfactory results. Therefore, this study focused on analyzing the effects of work values and leadership style—two variables recently recognized as important determinants of employee job satisfaction—on job satisfaction, employing them as antecedent variables. The research findings revealed that individuals' work values and their supervisors' leadership style not only directly influence job satisfaction but also partially exert influence through an interaction between these two variables. However, no significant interaction effect was found between the consideration and initiating structure dimensions of leadership style. Additionally, leadership style was found to have relatively stronger predictive power for job satisfaction compared to work values.