Why do users come to avoid mobile social networking? This study aimed to identify the causes of stress arising from mobile SNS use and to causally examine the effect of perceived stress on SNS continuance intention, thereby deriving implications. While existing studies have either explored the effects of devices' physical attributes on users' fatigue perception or remained at the level of measuring individual responses centered on specific functions, this study more systematically examines the antecedent-consequent relationships of stress generation in the mobile SNS usage context through the analytical framework of a process-based stress model. Meanwhile, this study utilized information overload and relationship burden as sub-concepts of stress factors for the conceptualization of mobile SNS stress, and considered not only technology-use contexts but also social contexts as environmental factors influencing these stress factors. The survey analysis results targeting mobile SNS users showed that, from a technological perspective, the usage environment that enables access anytime and anywhere and systems that enable multitasking can increase stress, while simple functionality can actually reduce the perception of stress. From a social influence perspective, both direct relationship-based influence and external influence were confirmed to have positive effects on relationship burden. Above all, the significance of this study lies in extending the context of existing stress theory to everyday information systems and in attempting to conceptualize mobile SNS stress.