The purpose of this study is to analyze the effects of introducing cellular layout to the facility layout of small and medium-sized enterprises engaged in high-variety low-volume production with traditional functional (process) layout. The analysis utilized actual data from Company S, which produces automobile parts. The parts of Company S were classified into 22 types according to process sequence and processing time per operation. The entire 22 types of parts were divided into 1, 2, and 5 cells through cluster analysis and constraints restricting the addition of expensive machines. Efficiency analysis was conducted through simulation experiments, and the simulation experiments in this study used the SLAM system/Windows version. The results showed that the cellular layout approach demonstrated better performance than the existing method in terms of: (1) job completion time, (2) average flow time, (3) queue length and waiting time, and (4) equipment utilization.